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Introduction

Paw Paw extract contains (among other active ingredients) acetogenins which modulate the production of ATP** (adenosine triphosphate) in mitochondria of cancer cells. This reduces the growth of blood vessels that nourish cancer cells. It also inhibits the growth of MDR (multiple drug resistance) cells. No other alternative or conventional cancer treatment (except treatments from trees similar to Paw Paw) has shown any effectiveness against MDR cells.

Paw Paw is a cousin of the graviola, guanabana, and soursop trees. However, the acetogenins extracted from Paw Paw are more active against cancer than those extracted from these other sources.                        

  Fruit of the Paw Paw Tree            

 Multiple Drug Resistant Cells
Most tumors contain a small percentage, approximately 2%, of multiple drug-resistant cells (MDR cells). Chemo is not effective against these cells. After the first round of chemo, if the chemo is effective, all of the cells that are not MDR, do not show up in scans. Since this accounts for the vast majority of the tumor mass, the tumor will appear to be effectively gone (gone where is something to consider). However, the MDR cells remain and start to multiply. Eventually, a new tumor is formed that is entirely MDR. The next time chemo is used, none of the cells will disapear because they are all MDR. Paw Paw and Graviola are the only cancer treatments that have shown effectiveness against MDR cells.

The Paw Paw Program, continues to help people gain and maintain health and disease free.

 With permission I am sharing a new cancer success story.

These stories I receive prove to me:

-that Nature's Sunshine products are meticulously quality controlled

-that all the NSP products have a high amount of nutrition and energy

-that this is a one stop shop; you have all you need with Nature's Sunshine

-that to be successful all 5 pillars must be addressed: injury, inflammation, elimination, ciruclation, infection

-that all kinds of cancers can be overcome

-that this program is more accurate than scientific studies as all the variables that affect cancer are controlled within this program.

-that it can take months to overcome cancer

-that this program is very inexpensive

-that you do not have to travel to a foreign country

-that you can do this program easily in the comfort of your own home

-that most people do not believe that they are capable of overcoming cancer with nutrition.

Cancer Success Story : Stomach Cancer /Lymphoma by Bachtiar


In June of 2013 Bachtiar was experiencing pain in the stomach. He couldn’t sleep and decided to see a doctor who gave him medication and ordered a H Pylori bacteria test. The test showed positive. The doctor also sent Bachtiar to a specialist.


On July 9, 2015 Bachtiar saw a stomach specialist who took pictures of the inside of the stomach and declared that this was cancer. The specialist immediately scheduled surgery so that Bachtiar’s stomach could be removed. This was an absolute shock to Bachtiar to think that his entire stomach would be removed. “ I was really scared!” Then a biopsy was done and the biopsy results indicated cancer of the lymph nodes in the stomach . The cancer was given the name lymphoma. In his state of despair Bachtiar resorted to prayer and meditation and he received his decision. When he saw the surgeon Bachtiar’s answer was clear.” I said No to surgery.” The surgeon then recommended chemotherapy and it was clearly explained to Bachtiar that his hair would fall out and that he would experience nausea. “ I said No to chemotherapy. This did not make sense to me; to put a poison into my body that would make me sick. I told the doctor I was going to try natural products.” The doctor immediatley ​stated with disapproval that natural products do not work and that Bactiar was making a mistake. “ I said to the doctor, it’s my body and I am going a different way.”

This is when Bachtiar contacted Donna Roth and asked for the Paw Paw program.

I was really strict with the program and I did exactly as suggested. I made 2 Smoothies a day with Mineral Chi Tonic, Collatrim Plus, Flax Lignans and Solstic Energy. I drank about ½ bottle of Aloe Vera juice every day. I took about 6 Paw Paw a day and 8 Cat’s Claw a day. On empty stomach I took Protease Plus enzymes and LBS11 to get my bowels really moving. I stopped eating all grains, all legumes , all sugar. This was really hard for me and it was a very strict diet but I believed that my body could heal.” Within 1 week of this program the stomach pains subsided and Bachtiar was able to sleep. “ I did this for 8 months and it cost me about $2000. My children all helped me to pay for the program. They all believed in it. I never went back to the doctor as I don’t trust their tests. I am not going back. I trusted this program and it worked. I know my cancer is gone.” As I write Bachtiar’s words it is August 18, 2015 and he has not had any symptoms of pain for 2 years now.
“ You cannot force people but I know it is a good product and I know the program works.”
Submitted to Lorene Benoit by Donna Roth, another practitioner who works with cancer. ​

Above Natures Sunshine Products available by clicking here to go to website:

 

Development

Paw Paw research was performed at Purdue College by Jerry McLaughlin. The majority of the funding (20 years and about 5 million dollars) for this research was provided by NCI. Jerry McLaughlin now works with Nature Sunshine who manufacture Paw Paw twig extract in capsule form.

Pharmacology    

One of the effects of Paw Paw is to reduce the ATP energy in each cell of our body. Our cells have an electrical potential that effects how the cell processes energy producing substances mostly blood sugar and oxygen from our blood supply (the red area in the graphic below).

                                                          

By reducing this voltage level from 70 to 110 mv to something in the 50 mv region, normal cells can still function. However, cancer and viral cells cannot process energy at this low voltage level and start to starve. The process of starving is a slower process than being poisoned which is why Paw Paw works slower than chemo. When Paw Paw does not work, it is usually because it is not absorbed sufficiently into the cells of the body to cause this voltage reduction. Both Cantron and Protocel are also designed to cause this voltage reduction. If Paw Paw does not work for a person, Cantron or Protocel may work. The pharmacology of Cantron and Protocel have an expanded explanation for the role ATP energy reduction in cancer treatment.
Blood Brain Barrier                                                 

Paw Paw is one of the few alternative cancer treatments that can pass the blood/brain barrier. The other alternative cancer treatments that can cross this barrier are Cantron and Protocel.

Effectiveness

Paw Paw seems to work on all types of cancers. An informal study of 100 cancer patients showed that Paw Paw was effective in half the cases. This is most interesting since Paw Paw seems to work the same way that Cancell (Cantron and Protocel) works and Cancell also has a 50% effectiveness as demonstrated in another informal study. However, Paw Paw gets higher marks in the effectiveness because, in the laboratory, it inhibits the growth of MDR (multiple drug resistance) cells. No other cancer treatment including chemo has shown any effectiveness against MDR cells. Jerry McLaughlin is in the negotiation process for starting clinical trials in conjunction with Harvard University. However, no formal clinical trials have yet occurred. For more on MDR cells, see the "Multiple Drug Resistant Cells" section above.

Studies

Here are a few abstracts from studies conducted at Purdue University where most of the Paw Paw research for the past 30 years was conducted:

ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.

ABSTRACT: Journal of Medicinal Chemistry 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.

Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.

Copies of the journal articles mentioned in the story are available from the Purdue News Service, (765) 494-2081.

Additional Paw Paw research papers can be see at PawPawResearch.com


Quantity of Papers

There have been over 100 scientific papers published on the chemistry and biology of the paw paw compounds.

Paw Paw and Viruses                                 

ATP is a direct and indirect precursor of DNA and RNA. This can slow or stop viral reproduction for viruses such as cold sores and shingles. Although the test results below show encouraging antiviral effect, it seems that Cancell (Cantron and Protocel) has a stronger antiviral effect. On the other hand Paw Paw has shown anecdotal evidence of being a strong anti-bacterial agent.

Conclusiveness of Papers


Almost all but research papers regarding Paw Paw demonstrate significant effectiveness in the laboratory against the usual form of cancer cells and MDR cells.


Standalone Ability

Considering the performance of Paw Paw in a study of 94 terminal cancer patients and its performance against MDR cells, it seems that Paw Paw would stand alone as a cancer treatment very well. However, the manufacture and developer feel that the following supplements would aid Paw Paw:


Dosage and Ease of Use


Paw Paw is easy to use. You only need two capsules, three times day, and taken with some food.

People who change their eating habits greatly increase the effectiveness of the supplements they take. Consider reading the Cancer Diets and pH* page.
Dosage

In March 2009, the Paw Paw produced by Natures Sunshine had reduced concentration of active ingredients due to a low yield harvest. To compensate Natures Sunshine increased the number of capsules in the bottle. Now the recommended dose for the new 8 mg of Asimina triloba per Paw Paw capsules is 2 capsules three times a day with food to avoid nausea.

Increased Dosage

Some people have had success gradually increasing the Paw Paw dosage up to 16 capsules a day. They have done this very gradually in order to avoid nausea.


Paw Paw and Cantron or Protocel


It is suggested to avoid food for 15 minutes before and after taking Cantron or Protocel, but to take Paw Paw with food. Taking Cantron or Protocel fifteen minutes before or after taking Paw Paw with some food does not seem to have a significant effect on the the performance of either treatment. See Cantron or Protocel and Paw Paw just below.
Regardless of treatment, recovery is much more likely if the emotional component
is addressed. Visit the Tapping DVD page to learn about the simplest and
most effective method to remove emotional bocks to your healing.

Side Effects

Paw Paw gravitates toward cells that use a lot of energy and cut off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice. It is also the reason that a pregnant woman should not take it. Paw Paw could see the baby as a high energy user.

If no cancer, parasite, or other high energy consumer cells reside in the body, Paw Paw may gravitate towards fast growing cells lining the digestive and intestinal system walls. This is why the manufacturer, Nature's Sunshine, strongly cautions against long term use for non-cancer patients.

Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.
Cantron or Protocel and Paw Paw

You can take Protocel with Paw Paw, but don't forget to read all the Paw Paw protocols under the Dosage and Ease of Use (above) and Compatability (just below) sections. Some people respond very quickly to Cantron or Protocel. In this case the body may have excessive waste material to remove. Paw Paw can increase the response of your body and overload the waste removal system. To present this overload, some people start Paw Paw 3 to 5 weeks after starting Cantron or Protocel or starting Paw Paw before Cantron or Protocel.

You should avoid food for 15 minutes before and after taking Cantron or Protocel, but you should have some food with Paw Paw. therefore, people take the Cantron or Protocel first, wait 15 minutes, eat a little and take the PawPaw. New recommended doseage for Paw Paw is 2 capsule three times a day. Since the recommended dose for Cantron or Protocel is six times a day, you alternate taking Paw Paw with Cantron or Protocel with just taking Cantron or Protocel. For example:

6 AM Cantron or Protocel, 6:15 AM Paw Paw

10 AM Cantron or Protocel

2 PM Cantron or Protocel, 2:15 PM Paw Paw

6 PM Cantron or Protocel

10 PM Cantron or Protocel, 10:15 PM Paw Paw

2 AM Cantron or Protocel

Since Paw Paw is fat soluble it will work better after a person has started eating for the day. Therefore, some users start taking Paw Paw with the second dose of Cantron or Protocel. See the Dosage section just above.

Compatibility

Paw Paw seems to work in a similar manner to Cancell and may reduce the side effects of chemo, but does not interfere with chemo.

Warning: If a cancer patient uses Paw Paw during a course of chemo, the reduced side effects caused by Paw Paw may encourage the oncologist to increase the dose of chemo. If the patient then decides to stop the Paw Paw, for whatever reason, the side effects of chemo can increase and greatly threaten the patients life.

One of the ways that Paw Paw works is to prevent cancer cells from feeding on glucose by reducing the ATP energy of the cells in our body. The substances in the following list increase ATP energy and should therefore be avoided when taking Paw Paw. Some people believe that you can take some of these things with Paw Paw because they were tested with Paw Paw and Paw Paw was still able to kill cancer cells in test tubes. However, Paw Paw works in a number of ways and those other ways may have been responsible for how Paw Paw worked with some of the things on this list.

Vitamins to Avoid
High concentrations of the following substances have been known to interfere with Cantron (naturally occurring quantities in food has not caused any problems):

Vitamin C (taking vitamin C is the number one reason that Paw Paw fails to work)
Vitamin E
Selenium
Thyroid support products
SOD
CoEnzyme Q10
"sea greens" such as spirulina, algae, chlorella, kelp may have a problem

The amount of vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.

The following counter the effects of Paw Paw:


Burdock Root
Essiac tea and Flor-Essence (which is similar to Essiac with a couple of extra ingredients)
Ozone treatments ( oxygen treatments such as hyperbaric oxygen are beneficial to the functioning of Protocel)
Flax seed oil as used in the Budwig diet (also spelled flaxseed oil). It is starting to appear that flax seed oil may be compatible, but it remains on this list as a precaution
IP6 (in theory there may be a problem, but case histories are needed)
714-x
Hydrogen peroxide
PMB Techno
Creatine
Cellect
Ginseng
Glutamine
Taurine
Rhodiola Rhosea
D-Ribose
Magnesium In higher doses, magnesium is credited with increasing ATP production.
L-Carnitine
Resveratrol
Colloidal silver - the heavy metal quality of silver could cause a reaction with Protocel.
Pau d'arco with Germanium-132 (taking either separately with Protocel is OK)
Grapefruit seed extract (due to its high vitamin C content)
Whey protein should also be avoided because of the L-cysteine
Iodine
IGF
Enercel
MSM
Cesium Chloride
Poly-MVA because of the alpha-lipoic acid
Hormone-Blocking Drugs
Immunocal
MMS (Miracle Mineral Supplement) chlorine dioxide
Sulfhydrazly antioxidants which includes:
L-cysteine
N-acetylsteine
Alpha-lipoic acid
Glutathion

For a list of treatments that are believed to be compatible with Paw Paw see the "Treatments that Can Be Taken with Cantron" list in the Compatibility section of the Cantron page.

Year Available

Paw Paw was made available for purchase by Nature's Sunshine in 2003. Since Paw Paw and graviola are so closely related it should be noted that graviola has been under study and available to a limited extent since the 1940's.

Relative Cost per Month

A one-month supply of Paw Paw costs $40 for 180 capsules. The standard dose is six capsules a day so one bottle is a one month supply. This makes Paw Paw one of the least expensive alternative cancer treatment available. Each capsule contains 8 mg of standardized paw paw extract Asimina triloba.


Insure Success After Ordering Paw Paw

Almost every cancer survivor who used alternatives used two or more treatments. After you order Paw Paw, ask your body to select a cancer treatment to add to your protocol using the Alternative Cancer Test Kit MRS Cards.



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